GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THYM | cis | rs1451375 | 1 | rs10247443 | chr7:50620586 | FIGNL1 | chr7:50511834-50518088:- | -0.3 | -4.59 | 1.33E-5 | Malaria |
| THYM | cis | rs2243480 | 1 | rs10247526 | chr7:65780696 | CCT6P1 | chr7:65216092-65228661:+ | -0.64 | -5.23 | 1.0E-6 | Diabetic kidney disease |
| THYM | cis | rs1451375 | 1 | rs10250513 | chr7:50621488 | FIGNL1 | chr7:50511834-50518088:- | -0.3 | -4.64 | 1.09E-5 | Malaria |
| THYM | cis | rs9815354 | 1 | rs1025646 | chr3:41754422 | ULK4 | chr3:41288091-42003660:- | 0.99 | 10.12 | 9.3E-17 | Diastolic blood pressure |
| THYM | cis | rs2143950 | 1 | rs1028449 | chr14:35512995 | KIAA0391 | chr14:35591776-35786673:+ | 0.32 | 4.18 | 6.43E-5 | Atopic dermatitis |
| THYM | cis | rs2143950 | 1 | rs1028449 | chr14:35512995 | PPP2R3C | chr14:35554679-35591679:- | 0.27 | 5.03 | 2.32E-6 | Atopic dermatitis |
| THYM | cis | rs10416265 | 1 | rs10416218 | chr19:33599127 | GPATCH1 | chr19:33571786-33621318:+ | 0.37 | 4.33 | 3.69E-5 | Bone properties (heel) |
| THYM | cis | rs10416265 | 1 | rs10416265 | chr19:33605300 | GPATCH1 | chr19:33571786-33621318:+ | 0.37 | 4.23 | 5.33E-5 | Bone properties (heel) |
| THYM | cis | rs10416265 | 1 | rs10423531 | chr19:33600140 | GPATCH1 | chr19:33571786-33621318:+ | 0.37 | 4.33 | 3.69E-5 | Bone properties (heel) |
| THYM | cis | rs8078723 | 1 | rs1042658 | chr17:38173902 | GSDMA | chr17:38119226-38134019:+ | -0.87 | -9.32 | 4.71E-15 | Neutrophil count;White blood cell count;C-reactive protein and white blood cell count |
| THYM | cis | rs703842 | 1 | rs10431505 | chr12:58178589 | FAM119B | chr12:58166383-58176323:+ | 0.41 | 5.83 | 7.7E-8 | Multiple sclerosis |
| THYM | cis | rs703842 | 1 | rs10431505 | chr12:58178589 | TSFM | chr12:58176536-58191367:+ | -0.28 | -5.16 | 1.33E-6 | Multiple sclerosis |
| THYM | cis | rs7072122 | 1 | rs10437514 | chr10:45048646 | ZNF22 | chr10:45496273-45500776:+ | 0.58 | 5.21 | 1.1E-6 | Estradiol plasma levels (breast cancer) |
| THYM | cis | rs7072122 | 1 | rs10437520 | chr10:45047427 | ZNF22 | chr10:45496273-45500776:+ | 0.47 | 4.63 | 1.16E-5 | Estradiol plasma levels (breast cancer) |
| THYM | cis | rs6087771 | 1 | rs10439607 | chr20:30258541 | MYLK2 | chr20:30407178-30422500:+ | 0.41 | 4.14 | 7.63E-5 | Subcortical brain region volumes |